DevMesh

Computationally Modelling Microglial Polarization in Neurodegenerative Disease

Rohan Sethi

Rohan Sethi

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Devloping a mathematical dynamic model of microglia polarization to reveal intrinsic mechanisms of proinflammatory microglial resolution. I expect to see oscillatory retreat to a dampened inflammatory state isolated from external intervention. ...learn more

Project status: Under Development

oneAPI

Intel Technologies
oneAPI

Overview / Usage

This project involves designing and computational fitting mathematical models to represent the biologically accurate mechanisms of microglial behavior. The goal is to understand how microglia respond to continuous pro-inflammatory stimulation and if the microglial cells have an intrinsic mechanism or require an antagonizing ligand to return back to original state. This type of behavior is not clearly mapped, especially for the PI3K/Akt pathway effectors. Understanding this behavior will pinpoint pathway effectors that can be leveraged to resolve damaging inflammation in neurodegenerative disease.

Methodology / Approach

  1. Extensive literature review and selection of a pathway network that is involved in microglial polarization

  2. Development of ODEs modelling pathway component interactions

  3. Research and implementation of goodwin oscillator to negative feedback pathway interactions

  4. Fit model using quadratic optimization solvers to minimize regression loss function

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